Circulating CD34+VEGFR-2+ endothelial progenitor cells correlate with revascularization-mediated long-term improvement of cardiac function in patients with coronary chronic total occlusions
| Autor: | Yuxiang Dai, Jia Huang, Hao Lu, Zheyong Huang, Juying Qian, Yinyin Chen, Shufu Chang, Lei Ge, Daoyuan Ren, Junbo Ge, Chenguang Li, Feng Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Angiogenesis medicine.medical_treatment CD34 030204 cardiovascular system & hematology Revascularization Peripheral blood mononuclear cell 03 medical and health sciences 0302 clinical medicine Percutaneous Coronary Intervention Internal medicine medicine Humans 030212 general & internal medicine Prospective Studies Progenitor cell Endothelial Progenitor Cells business.industry Percutaneous coronary intervention Vascular Endothelial Growth Factor Receptor-2 Coronary Occlusion Conventional PCI cardiovascular system Cardiology Quality of Life Cardiology and Cardiovascular Medicine business |
| Zdroj: | International journal of cardiology. 322 |
| ISSN: | 1874-1754 |
| Popis: | Endothelial progenitor cells (EPCs) participate in angiogenesis and neocollateralization. This study assessed if circulating EPCs can predict long-term improvement of global left ventricular systolic function in patients with coronary chronic total occlusions (CTOs) underwent successful percutaneous coronary intervention (PCI).In this single-center, prospective, observational study, 115 consecutive patients with CTOs were evaluated by standard transthoracic echocardiography (ECHO) before and 9-12 months after PCI. Numbers of circulating putative EPCs were determined by flow cytometry analysis of mononuclear cells isolated from peripheral blood samples drawn before and 72 h after PCI.At mean 11.3 ± 2.5 months post vs. before PCI (all P .05): by SAQ-7 summary scores, angina frequency, physical limitation and quality of life scores were greater; by ECHO, LVEDd decreased and LVEF increased, which were more significant in patients with Rentrop grades 2/3 vs. 0/1. At 72 h post vs. before PCI, CD34In this small study, the baseline levels of circulating CD34 |
| Databáze: | OpenAIRE |
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