Neurochemical and Cognitive Beneficial Effects of Moderate Physical Activity and Catechinin Aged Rats
Autor: | M. Ramis, Jerònia Lladó, David Moranta, Susana Esteban, Fiorella Sarubbo, Antoni Miralles, Silvia Tejada |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
brain health Physiology Clinical Biochemistry Noradrenaline (NA) 5-HT Hippocampus physical activity Physical exercise RM1-950 Pharmacology medicine.disease_cause Biochemistry Neuroprotection Article memory 03 medical and health sciences 0302 clinical medicine Neurochemical monoamines SIRT1 catechin Monoaminergic Medicine Dopamine (DA) Molecular Biology business.industry aging Cell Biology Motor coordination 030104 developmental biology Monoamine neurotransmitter Therapeutics. Pharmacology business 030217 neurology & neurosurgery Oxidative stress |
Zdroj: | Antioxidants Volume 10 Issue 4 Antioxidants, Vol 10, Iss 621, p 621 (2021) |
ISSN: | 2076-3921 |
DOI: | 10.3390/antiox10040621 |
Popis: | A healthy aging process is a requirement for good life quality. A relationship between physical activity, the consumption of antioxidants and brain health has been stablished via the activation of pathways that reduce the harmful effects of oxidative stress, by inducing enzymes such as SIRT1, which is a protector of brain function. We analyzed the cognitive and neurochemical effects of applying physical exercise in elderly rats, alone or in combination with the antioxidant catechin. Several tests of spatial and episodic memory and motor coordination were evaluated. In addition, brain monoaminergic neurotransmitters and SIRT1 protein levels were assessed in the brains of the same rats. The results show that physical activity by itself improved age-related memory and learning deficits, correlating with the restoration of brain monoaminergic neurotransmitters and SIRT1 protein levels in the hippocampus. The administration of the antioxidant catechin along with the exercise program enhanced further the monoaminergic pathways, but not the other parameters studied. These results agree with previous reports revealing a neuroprotective effect of physical activity, probably based on its ability to improve the redox status of the brain, demonstrating that exercise at an advanced age, combined with the consumption of antioxidants, could produce favorable effects in terms of brain health. |
Databáze: | OpenAIRE |
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