Pharmacogenomics Variability of Lipid-Lowering Therapies in Familial Hypercholesterolemia
| Autor: | Georges Nemer, Jamil Alenbawi, Nagham N. Hindi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
pharmacogenomics
familial hypercholesterolemia business.industry Genomic data Genomic sequencing Medicine (miscellaneous) Familial hypercholesterolemia Computational biology Review medicine.disease novel lipid-lowering therapy statins Exponential expansion PCSK9 inhibitors Pharmacogenomics medicine Medicine Lipid lowering Personalized medicine business Dyslipidemia ezetimibe |
| Zdroj: | Journal of Personalized Medicine Journal of Personalized Medicine, Vol 11, Iss 877, p 877 (2021) |
| ISSN: | 2075-4426 |
| Popis: | The exponential expansion of genomic data coupled with the lack of appropriate clinical categorization of the variants is posing a major challenge to conventional medications for many common and rare diseases. To narrow this gap and achieve the goals of personalized medicine, a collaborative effort should be made to characterize the genomic variants functionally and clinically with a massive global genomic sequencing of “healthy” subjects from several ethnicities. Familial-based clustered diseases with homogenous genetic backgrounds are amongst the most beneficial tools to help address this challenge. This review will discuss the diagnosis, management, and clinical monitoring of familial hypercholesterolemia patients from a wide angle to cover both the genetic mutations underlying the phenotype, and the pharmacogenomic traits unveiled by the conventional and novel therapeutic approaches. Achieving a drug-related interactive genomic map will potentially benefit populations at risk across the globe who suffer from dyslipidemia. |
| Databáze: | OpenAIRE |
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