Doxorubicin-reinforced supramolecular hydrogels of RGD-derived peptide conjugates for pH-responsive drug delivery
| Autor: | Keming Xu, Ziran Zhai, Tingting Zhu, Wenying Zhong, Suyun He, Leixia Mei |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Drug
Cell Survival Macromolecular Substances media_common.quotation_subject Peptide macromolecular substances 02 engineering and technology 010402 general chemistry 01 natural sciences Biochemistry Drug Delivery Systems Tumor Cells Cultured Tumor Microenvironment medicine Humans Doxorubicin Physical and Theoretical Chemistry Cell Proliferation media_common chemistry.chemical_classification Antibiotics Antineoplastic Microscopy Confocal Organic Chemistry technology industry and agriculture Hydrogels Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences chemistry Nanofiber Drug delivery Self-healing hydrogels Biophysics Peptides 0210 nano-technology Oligopeptides medicine.drug Conjugate |
| Zdroj: | Organic & Biomolecular Chemistry. 17:3853-3860 |
| ISSN: | 1477-0539 1477-0520 |
| Popis: | Drug incorporation in hydrogels often brings undesirable effects on the stability or mechanical properties of the system. To address this problem, we report the design and synthesis of a RGD-derived peptide conjugate (1-RGDH) for its co-assembly with a commonly used chemotherapeutic drug, doxorubicin (DOX), that formed electrostatic interactions with the 1-RGDH peptide and reinforced the supramolecular network of nanofibers within the matrix of the hydrogel. The hybrid hydrogel demonstrated excellent viscoelastic and shear-thinning properties that greatly facilitated the development of injectable drug delivery systems. Furthermore, it demonstrated a unique pH responsive release of DOX under weakly acidic conditions, paving ways for the controlled release of drug cargos in a typical tumor microenvironment with mild acidity. Finally, the DOX-incorporated hydrogel exhibited a superior anti-tumor efficacy in non-small-cell lung cancer cells A549 compared to the aqueous solution of free DOX, with an integrin receptor-mediated endocytosis pathway revealed for the cellular uptake of DOX-incorporated nanofibers. |
| Databáze: | OpenAIRE |
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