| Autor: |
Wenzhuo Zhuang, Bingzong Li, Zhengyi Li, Wenyue Zhuang, Yating Hong, Wenqi Zhou, Yingchun Qiu, Chen'ao Qian, Nengjun Yi, Sha Song, Huiying Han, Hongxia Xu |
| Rok vydání: |
2023 |
| Popis: |
Supplemental materials and methods, Table S1-S7, Figure S1-5. Supplementary Table 1. Characterization of myeloma patients Supplementary Table 2. Primers used in this study Supplementary Table 3. Sequences of siRNA against specific target in this study Supplementary Table 4, 5. In silico analysis of PSMA3-AS1 coding potential. Supplementary Table 5. Prediction of putative proteins encoded by PSMA3-AS1 using CPAT. 19 Supplementary Table 6. Summary for the results of univariate multivariable analysis. Supplementary Table 7. C-index of ISS alone, ISS with PSMA3, and ISS with PSMA3-AS1 Figure S1. MSCs derived exosomes were transferred to myeloma cells and conferred proteasome inhibitors resistance to myeloma cells. Figure S2. Identifying mRNAs involved in bortezomib-resistant patients. Figure S3. Exosome-mediated transfer of PSMA3 and PSMA3-AS1 from MSCs to MM cells contributed to proteasome inhibitors resistance. Figure S4. PSMA3-AS1 reduced proteasome inhibitors sensitivity by regulating PSMA3 expression in MM cells. Figure S5. PSMA3-AS1 formed an RNA duplex with PSMA3-AS1 pre-mRNA and increased its stability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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