Dramatic decline in circulating intercellular adhesion molecule-1 concentration on quitting tobacco smoking
Autor: | David A Scott, John A Stapleton, Ron F Wilson, Gay Sutherland, Richard M Palmer, Paula Y Coward, Gunnar Gustavsson |
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Rok vydání: | 2000 |
Předmět: |
Adult
Male Time Factors medicine.medical_treatment Intercellular Adhesion Molecule-1 Physiology Health benefits Quit smoking Mean difference chemistry.chemical_compound parasitic diseases medicine Humans Molecular Biology Smoke business.industry Smoking Follow up studies Cell Biology Hematology stomatognathic diseases chemistry Molecular Medicine Smoking cessation Regression Analysis Female Smoking Cessation Cotinine business Biomarkers Follow-Up Studies |
Zdroj: | Blood cells, moleculesdiseases. 26(3) |
ISSN: | 1079-9796 |
Popis: | The concentration of soluble ICAM-1 (sICAM-1) is significantly elevated in smokers, but it is unclear if smoking is the direct cause of elevated sICAM-1 levels, if the relationship between smoking and sICAM-1 level is dose-dependent, and if smoking cessation may lead to a decline in sICAM-1. We sought to clarify the relationship between smoking and sICAM-1 in a group of smokers who quit smoking for 1 year (n = 30) and a control group who continued to smoke (n = 30). A dose-dependent relationship between plasma sICAM-1 concentration and daily cigarette consumption (P = 0.02), plasma cotinine level (P = 0.02), and expired CO level (P = 0.007) was observed at baseline (n = 60). The mean change in sICAM-1 concentration after 52 weeks was greater for quitters than for continuing smokers (mean difference = -71.1 ng/ml, P < 0.001). The influence of smoking on sICAM-1 needs to be carefully considered in clinical trials. Soluble ICAM-1 remains bioactive and may contribute to pathogenic processes; therefore, reduction in the concentration of circulating ICAM-1 molecules may directly contribute to the health benefits associated with smoking cessation. |
Databáze: | OpenAIRE |
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