What’s 'up'? Impaired Spatial Preposition Processing in Posterior Cortical Atrophy
Autor: | Zubaida Shebani, Peter J. Nestor, Friedemann Pulvermüller |
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Rok vydání: | 2021 |
Předmět: |
spatial prepositions
posterior cortical atrophy Neurosciences. Biological psychiatry. Neuropsychiatry spatial language processing semantic processing working memory 050105 experimental psychology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Medicine 0501 psychology and cognitive sciences Biological Psychiatry Original Research PCA business.industry embodiment cognition 05 social sciences Posterior cortical atrophy Human Neuroscience Anatomy category specific impairments Psychiatry and Mental health Neuropsychology and Physiological Psychology Neurology business 030217 neurology & neurosurgery RC321-571 |
Zdroj: | Frontiers in Human Neuroscience, Vol 15 (2021) Frontiers in Human Neuroscience |
ISSN: | 1662-5161 |
Popis: | This study seeks to confirm whether lesions in posterior regions of the brain involved in visuo-spatial processing are of functional relevance to the processing of words with spatial meaning. We investigated whether patients with Posterior Cortical Atrophy (PCA), an atypical form of Alzheimer’s Disease which predominantly affects parieto-occipital brain regions, is associated with deficits in working memory for spatial prepositions. Case series of patients with PCA and matched healthy controls performed tests of immediate and delayed serial recall on words from three lexico-semantic word categories: number words (twelve), spatial prepositions (behind) and function words (e.g., shall). The three word categories were closely matched for a number of psycholinguistic and semantic variables including length, bi-/tri-gram frequency, word frequency, valence and arousal. Relative to controls, memory performance of PCA patients on short word lists was significantly impaired on spatial prepositions in the delayed serial recall task. These results suggest that lesions in posterior parieto-occipital regions specifically impair the processing of spatial prepositions. Our findings point to a pertinent role of posterior cortical regions in the semantic processing of words with spatial meaning and provide strong support for modality-specific semantic theories that recognize the necessary contributions of sensorimotor regions to conceptual semantic processing. |
Databáze: | OpenAIRE |
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