Absence of Uptake and Prion-Like Spreading of Alpha-Synuclein and Tau After Intravitreal Injection of Preformed Fibrils
| Autor: | Michel Mahieu, Lies De Groef, Jessie Van Houcke, Sophie Van Pottelberge, Dieder Moechars, Jeroen Aerts, Lien Veys, Audrey Coens, Ronald Melki, Louis De Muynck |
|---|---|
| Přispěvatelé: | Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Janssen Research & Development, Centre National de la Recherche Scientifique (CNRS), Molecular Imaging Research Center [Fontenay-aux-Roses] (MIRCen), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging [SDV]Life Sciences [q-bio] Cognitive Neuroscience alpha-synuclein Protein aggregation Fibril lcsh:RC321-571 Extracellular matrix 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine prion-like spreading medicine tau Prion protein lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Alpha-synuclein Retina intravitreal injection Brief Research Report 030104 developmental biology medicine.anatomical_structure chemistry visual system Protein folding Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Aging Neuroscience Frontiers in Aging Neuroscience, Vol 12 (2021) Frontiers in Aging Neuroscience, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩ Frontiers in Aging Neuroscience, Frontiers, 2021, 12, pp.614587. ⟨10.3389/fnagi.2020.614587⟩ |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2020.614587⟩ |
| Popis: | Although very different in etiology and symptoms, numerous neurodegenerative diseases can be classified as proteinopathies. More so, evidence indicates that the key misfolded proteins at the basis of different neuropathies might share common mechanisms of propagation. As such, the prion-like spreading of protein aggregates through the neural network is subject of intensive research focus and requires adequate models. Here, we made use of the well-defined architecture and large accessibility of the visual system, of which the retinotopic connections represent a simple route of anterograde signaling and an elegant model to investigate transsynaptic, prion-like spreading. In two independent studies, uptake and seeding of alpha-synuclein and tau were examined after intravitreal injection of preformed fibrils. However, extracellular matrix components in the vitreous space and at the vitreoretinal surface appeared to act as a barrier for the entry of both fibrils into the retina. These results show that further experimental refinement is needed to fully realize the potential of the visual system as a model for studying the molecular and cellular mechanisms of anterograde, transsynaptic spreading of prion-like proteins. ispartof: Frontiers In Aging Neuroscience vol:12 pages:1-11 ispartof: location:Switzerland status: Published online |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|