Application of genomics to toxicology research

Autor:	Gina M. Zastrow, Kalyan Pande, Stevan B. Jovanovich, Sharron G. Penn, Russell S. Thomas, Mark H. Lewis, Tianhua Hu, Christopher A. Bradfield, David R. Rank, Kevin R. Hayes
Rok vydání:	2002
Předmět:	Polymorphism Genetic Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Genomics Biology Toxicology Disease Models Animal Gene Expression Regulation Toxicity Tests Animals Humans Environmental Pollutants Genomic information Toxicogenomics Research Article Forecasting Oligonucleotide Array Sequence Analysis
Zdroj:	Environmental Health Perspectives
ISSN:	1552-9924 0091-6765
DOI:	10.1289/ehp.02110s6919
Popis:	Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635be343845f4df57d414a107e4e32cc https://doi.org/10.1289/ehp.02110s6919 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.