Application of genomics to toxicology research
| Autor: | Gina M. Zastrow, Kalyan Pande, Stevan B. Jovanovich, Sharron G. Penn, Russell S. Thomas, Mark H. Lewis, Tianhua Hu, Christopher A. Bradfield, David R. Rank, Kevin R. Hayes |
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| Rok vydání: | 2002 |
| Předmět: |
Polymorphism
Genetic Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Genomics Biology Toxicology Disease Models Animal Gene Expression Regulation Toxicity Tests Animals Humans Environmental Pollutants Genomic information Toxicogenomics Research Article Forecasting Oligonucleotide Array Sequence Analysis |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| Popis: | Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility. |
| Databáze: | OpenAIRE |
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