Serum Micro-RNA-122 Level as a Simple Noninvasive Marker of MAFLD Severity
| Autor: | Ibrahim Abd ALgwad, Mona A. Hegazy, Mohamed Sayed Hassan, Soheir Abu El Fadl, Laila A. Rashed, Maha Assem Hussein |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
MAFLD 030209 endocrinology & metabolism Physical examination Disease 030204 cardiovascular system & hematology Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Fibrosis Internal medicine microRNA Internal Medicine medicine Targets and Therapy [Diabetes Metabolic Syndrome and Obesity] Original Research Pharmacology medicine.diagnostic_test Cholesterol business.industry Fatty liver medicine.disease micro RNA chemistry steatosis and fibrosis Steatosis business Lipid profile |
| Zdroj: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| ISSN: | 1178-7007 |
| Popis: | Mona A Hegazy,1 Ibrahim Abd ALgwad,1 Soheir Abuel Fadl,1 Mohamed Sayed Hassan,1 Laila Ahmed Rashed,2 Maha A Hussein1 1Internal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, Egypt; 2Biochemistry Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptCorrespondence: Mona A HegazyInternal Medicine Department, Kasr Al-Aini Hospitals, Cairo University, Cairo, EgyptEmail monahegazy@cu.edu.egBackground: Metabolic-associated fatty liver disease (MAFLD) is a common disease worldwide. Micro-RNA-122 is known to be the most abundant micro-RNA expressed in the liver.Objective: To evaluate the association of micro-RNA-122 and the degree of steatosis and fibrosis in obese patients with MAFLD.Methods: The study included 120 obese Egyptian patients with MAFLD, which were diagnosed and classified according to ultra-sonographic liver findings. All patients enrolled in the study were subjected to thorough clinical examination and laboratory investigations (serum micro-RNA-122 levels by PCR, lipid profile, liver biochemistry, and functions). Fibro-scan was used to assess the level of fibrosis.Results: There was a significant increase in levels of micro-RNA-122 in obese patients with MAFLD compared to controls (p< 0.001). Micro-RNA-122 level was lower in patients with mild liver steatosis than patients with moderate or severe steatosis (p< 0.001). It was lower in patients with a mild degree of fibrosis than those with mild or moderate fibrosis (p< 0.001). Micro-RNA-122 was significantly positively correlated with low-density cholesterol and triglycerides level, and liver enzymes, and negatively correlated to high-density cholesterol (p< 0.001).Conclusion: Serum micro-RNA-122 could be a useful predictor of assessing MAFLD severity regarding level of steatosis or fibrosis.Keywords: MAFLD, micro RNA, steatosis and fibrosis |
| Databáze: | OpenAIRE |
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