| Autor: |
Xing Ma, Dekai Zhou, Dandan Xu, Mingze Sun, Xiaohui Yan, Xi Pan, Xiuzhen Tang, Xiaojia Liu |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
ACS Applied Bio Materials. 3:1434-1443 |
| ISSN: |
2576-6422 |
| DOI: |
10.1021/acsabm.9b01086 |
| Popis: |
Hollow mesoporous silica nanoparticles (HMSNPs) have been widely explored in the biomedical field as drug delivery nanocarriers by virtue of their large hollow cavity. However, the connectivity between the internal cavity and the outside environment by numerous nanochannels on the mesoporous shell allows for possible drug leakage, leading to nonsufficient drug loading due to unreliable capping of the nanopores. In addition, the issue of ensuring effective utilization of the hollow cavity for achieving high drug loading capacity of HMSNPs is seldom addressed. Thus, in this work, HMSNPs with the diameter of about 400 nm were prepared and completely encapsulated by growing an ultrathin nanolayer of aluminum oxide (Al |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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