Uvaol Improves the Functioning of Fibroblasts and Endothelial Cells and Accelerates the Healing of Cutaneous Wounds in Mice
| Autor: | Jamylle Nunes de Souza Ferro, Polliane Maria Cavalcante-Araújo, Emiliano Barreto, Juliane Pereira da Silva, Vincent Lagente, Julianderson de Oliveira dos Santos Carmo, Ana Carolina de Carvalho Correia |
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| Přispěvatelé: | Universidade Federal de Alagoas = Federal University of Alagoas (UFAL), Universidade Federal Rural de Pernambuco (UFRPE), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
uvaol
Cell Survival MAP Kinase Signaling System [SDV]Life Sciences [q-bio] Pharmaceutical Science wound healing p38 Mitogen-Activated Protein Kinases Article Analytical Chemistry lcsh:QD241-441 03 medical and health sciences Mice 0302 clinical medicine lcsh:Organic chemistry Laminin In vivo Cell Movement fibroblasts Drug Discovery Animals Physical and Theoretical Chemistry 030304 developmental biology Skin Tube formation 0303 health sciences biology Chemistry Organic Chemistry Cell migration In vitro Triterpenes endothelial cells 3. Good health Cell biology Extracellular Matrix Fibronectin [SDV] Life Sciences [q-bio] terpenes medicinal Kinetics Chemistry (miscellaneous) 030220 oncology & carcinogenesis biology.protein Molecular Medicine Signal transduction Wound healing |
| Zdroj: | Molecules, Vol 25, Iss 4982, p 4982 (2020) Molecules Molecules, MDPI, 2020, 25 (21), ⟨10.3390/molecules25214982⟩ Volume 25 Issue 21 Molecules, 2020, 25 (21), ⟨10.3390/molecules25214982⟩ |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25214982⟩ |
| Popis: | International audience; Uvaol is a natural pentacyclic triterpene that is widely found in olives and virgin olive oil, exerting various pharmacological properties. However, information remains limited about how it affects fibroblasts and endothelial cells in events associated with wound healing. Here, we report the effect of uvaol in the in vitro and in vivo healing process. We show the positive effects of uvaol on migration of fibroblasts and endothelial cells in the scratch assay. Protein synthesis of fibronectin and laminin (but not collagen type I) was improved in uvaol-treated fibroblasts. In comparison, tube formation by endothelial cells was enhanced after uvaol treatment. Mechanistically, the effects of uvaol on cell migration involved the PKA and p38-MAPK signaling pathway in endothelial cells but not in fibroblasts. Thus, the uvaol-induced migratory response was dependent on the PKA pathway. Finally, topical treatment with uvaol caused wounds to close faster than in the control treatment using experimental cutaneous wounds model in mice. In conclusion, uvaol positively affects the behavior of fibroblasts and endothelial cells, potentially promoting cutaneous healing. |
| Databáze: | OpenAIRE |
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