Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort

Autor: Segura, Alex G., Martínez Pinteño, Albert, Gassó Astorga, Patricia, Rodríguez Ferret, Natalia, Bioque Alcázar, Miquel, Cuesta, Manuel J., González Peñas, Javier, García Rizo, Clemente, Lobo, Antonio, González-Pinto, Ana, García Alcón, Alicia, Roldán, Alexandra, Vieta i Pascual, Eduard, 1963, Castro Fornieles, Josefina, Mané Santacana, Anna, Saiz Ruiz, Jerónimo, Bernardo Arroyo, Miquel, Mas Herrero, Sergi, Mezquida Mateos, Gisela, PEPs Group
Rok vydání: 2022
Předmět:
Zdroj: Addi. Archivo Digital para la Docencia y la Investigación
instname
SCHIZOPHRENIA RESEARCH
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
ISSN: 0920-9964
Popis: [EN] Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common genetic background of psychotic and metabolic disorders. In this study, we aimed to assess the role of polygenic risk scores (PRSs) on the progression of the metabolic profile in a first-episode psychosis (FEP) cohort. Method: Of the 231 FEP individuals included in the study, 192-220 participants were included in basal analysis and 118-179 in longitudinal 6-month models. Eleven psychopathologic and metabolic PRSs were constructed. Basal and longitudinal PRSs association with metabolic measurements was assessed by statistical analyses.Results: No major association of psychopathological PRSs with the metabolic progression was found. However, high risk individuals for depression and cholesterol-related PRSs reported a higher increase of cholesterol levels during the follow-up (FDR
Databáze: OpenAIRE
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