Feasibility and outcome of complete secondary tumor resection for patients with advanced ovarian cancer
| Autor: | George Blackledge, K. K. Chan, David Luesley, Frank Lawton, Charles W.E. Redman, Raiiv Varma |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Reoperation medicine.medical_specialty medicine.medical_treatment Tumor resection Ovary Laparotomy Antineoplastic Combined Chemotherapy Protocols Humans Medicine Prospective Studies Prospective cohort study Aged Neoplasm Staging Ovarian Neoplasms Stage III Ovarian Cancer Chemotherapy business.industry Carcinoma Cancer General Medicine Middle Aged Prognosis medicine.disease Debulking Combined Modality Therapy Surgery medicine.anatomical_structure Oncology Female Cisplatin business |
| Zdroj: | Journal of Surgical Oncology. 45:14-19 |
| ISSN: | 1096-9098 0022-4790 |
| DOI: | 10.1002/jso.2930450105 |
| Popis: | From November 1981 to July 1985, 124 women with International Federation of Gynecology and Obstetrics (FIGO) stage III ovarian cancer were treated in prospective studies of surgery and chemotherapy in our institution. Patients with no macroscopic cancer after primary surgery (n = 16) received five cycles of adjuvant cis-platinum; those with residual cancer after primary laparotomy (n = 108) underwent a second surgical debulking after three or five cycles of cis-platinum-based cytoreductive chemotherapy. Total macroscopic tumor clearance was achieved in 26 of these 108 patients. Fourteen patients with total tumor excision at primary laparotomy remain in complete clinical remission a minimum of 36 months after diagnosis, but the median progression-free interval for the other two groups was 9 and 17 months, respectively. The survival for women who have total tumor clearance only at secondary surgery after chemotherapy is inferior to that for women with primary macroscopic tumor excision followed by chemotherapy. |
| Databáze: | OpenAIRE |
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