mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors

Autor:	Ping Jun Zhu, Jacqunae Mays, Loredana Stoica, Chien-Ju Chen, Mauro Costa-Mattioli
Rok vydání:	2018
Předmět:	Male 0301 basic medicine rictor animal structures Regulator Hippocampus Mechanistic Target of Rapamycin Complex 2 mTORC1 Mechanistic Target of Rapamycin Complex 1 Hippocampal formation Receptors Metabotropic Glutamate mTORC2 Article memory mTOR complexes Mice 03 medical and health sciences 0302 clinical medicine mental disorders Animals Learning long-term depression Mice Knockout Sirolimus synaptic plasticity Behavior Animal Long-Term Synaptic Depression musculoskeletal neural and ocular physiology General Neuroscience Glutamate receptor Recognition Psychology Regulatory-Associated Protein of mTOR Electrophysiological Phenomena nervous system diseases Mice Inbred C57BL 030104 developmental biology Metabotropic receptor nervous system raptor Metabotropic glutamate receptor Space Perception Female Neuroscience 030217 neurology & neurosurgery
Zdroj:	Nature neuroscience
ISSN:	1546-1726 1097-6256
Popis:	The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. Interestingly, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63556736ef6fe8234b2fc3b604ab2a47 https://doi.org/10.1038/s41593-018-0156-7 Zobrazit plný text záznamu Full text from SpringerLink