A Novel Vascular Modulator, Hepatocyte Growth Factor (HGF), as a Potential Index of the Severity of Hypertension
| Autor: | Nobuaki Nakano, Shin-ichiro Hayashi, Atsushi Moriguchi, Toshio Ogihara, Jitsuo Higaki, Seiju Takami, Kunio Matsumoto, Sachiko Nakata, Tomohiro Katsuya, Motokuni Aoki, Shigefumi Nakamura, Toshikazu Nakamura, Ryuichi Morishita, Yoshikage Yo |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Biophysics Blood Pressure Biochemistry Muscle hypertrophy Internal medicine medicine Humans Endothelial dysfunction Molecular Biology Antihypertensive Agents Hepatocyte Growth Factor business.industry Cell Biology Middle Aged Serum concentration medicine.disease Endothelial stem cell Endocrinology Blood pressure medicine.anatomical_structure Evaluation Studies as Topic Hypertension Female Hepatocyte growth factor Endothelium Vascular Complication business medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 242:238-243 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1997.7800 |
| Popis: | HGF (hepatocyte growth factor), a member of endothelium-specific growth factors, might contribute to protection and/or repair of vascular endothelial cells injured by high blood pressure (BP). If so, serum HGF level might be elevated in response to endothelial cell damage. To test this hypothesis, we measured serum levels of HGF in hypertensive and normotensive patients. Serum HGF concentration in hypertensive patients without any complication was significantly higher than normal subjects (p < 0.001). Serum HGF concentration showed a significant positive correlation with BP (p < 0.01). Interestingly, serum HGF concentration in hypertensive patients with complications was significantly higher than that in hypertensive patients without complication and normotensive subjects (p < 0.01). Of importance, hypertensive patients treated with antihypertensive drugs showed the same level of serum HGF concentration as normotensive subjects (p < 0.001). The present study demonstrated that serum concentration of HGF is significantly elevated dependent on the severity of hypertension, suggesting that HGF may be a new index of the severity of hypertension. |
| Databáze: | OpenAIRE |
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