Acetyl- and Butyrylcholinesterase Activities Decrease in Human Colon Adenocarcinoma
| Autor: | Encarnación Muñoz-Delgado, María F. Montenegro, Juan Cabezas-Herrera, Francisco J. Campoy, Francisco Ruiz-Espejo, Cecilio J. Vidal, María Páez de la Cadena |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Colon
Aché Adenocarcinoma medicine.disease_cause Cellular and Molecular Neuroscience chemistry.chemical_compound Reference Values medicine Humans Butyrylcholinesterase Cholinesterase integumentary system biology Neurogenesis Rectum General Medicine medicine.disease Acetylcholinesterase Molecular biology language.human_language Kinetics chemistry Colonic Neoplasms biology.protein language Carcinogenesis Acetylcholine medicine.drug |
| Zdroj: | Journal of Molecular Neuroscience. 30:51-54 |
| ISSN: | 0895-8696 |
| DOI: | 10.1385/jmn:30:1:51 |
| Popis: | Apart from the hydrolysis of acetylcholine (ACh), acetyl- (AChE) and butyrylcholinesterase (BChE), through noncatalytic mechanisms, intervene in hematopoiesis, morphogenesis, and neurogenesis (Layer and Willbold, 1995; Soreq and Seidman, 2001). Cholinesterase (ChE) molecules occur as globular (G1, G2, and G4) and asymmetric (A4, A8, and A12) forms (Legay, 2000; Massoulié, 2002). The G species might display amphiphilic (GA) or hydrophilic (GH) properties (Perrier et al., 2002). The involvement of ChEs in tumorigenesis is supported by the measurement of ChE activity in tumors (García-Ayllón et al., 2001; Ruiz-Espejo et al., 2003), the amplification of ChE genes in leukemias and ovarian tumors, and the relationship between the expression of AChE and the aggressiveness of astrocytomas(Perry et al., 2002). This research was undertaken to determine whether ChE activity is altered in gut carcinomas. |
| Databáze: | OpenAIRE |
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