Cardiac involvement in cancer patients under chemotherapy and diagnosed with COVID-19: case report and literature review

Autor: Hanane Mechal, Rime Benmalek, Hamza Choukrallah, Anas Maaroufi, Rachida Habbal, El Ghali Mohamed Benounas, Anass Mounir, Khalid Allali, Rachid Cherkab, Lhoucine Barrou, Chafik El Kettani
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pan African Medical Journal; Vol. 41 No. 1 (2022)
ISSN: 1937-8688
Popis: Many cases of severe cardiac complications due to coronavirus disease 2019 (COVID-19) were reported. Cancer and chemotherapy appear to be risk and prognostic factors for COVID-19. A 49-year-old female, with a history of breast cancer treated by tumorectomy and anthracycline-based chemotherapy was admitted with acute respiratory distress syndrome (ARDS) confirmed as COVID-19. She also had elevated troponin I level (up to 43 g/L), and diffuse myocardial hypokinesia along with severe left ventricle dysfunction on echocardiography. Initial treatment includedhydroxychloroquine, azithromycin, corticosteroids and mechanical ventilation. The evolution was marked by QT interval prolongation (QTc=523 ms) and occurrence of cardiogenic shock. The patient died of hemodynamic instability reluctant to resuscitation measures at the 2ndday of hospitalization. COVID-19 patients may develop severe cardiac complications such as myocarditis and heart failure. Receiving chemotherapy especially anthracyclines may be a precipitating and prognostic factor of cardiac manifestations in COVID-19 cancer patients.
Databáze: OpenAIRE