Alterations in the physicochemical properties of renal cortical membranes in rats with experimental cirrhosis of the liver
| Autor: | Paloma Perez-Rodrigo, José M. López-Novoa, Francisco Gavilanes |
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| Předmět: |
Male
medicine.medical_specialty Cirrhosis Kidney Cortex Physiology Membrane Fluidity Membrane lipids Renal cortex Phospholipid Fluorescence Polarization Biology Liver Cirrhosis Experimental Biochemistry chemistry.chemical_compound Membrane Lipids Internal medicine medicine Membrane fluidity Animals Na+/K+-ATPase Phospholipids Cholesterol Cell Membrane Fatty Acids Membrane Proteins Rats Inbred Strains medicine.disease Rats Membrane Endocrinology medicine.anatomical_structure chemistry sense organs Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Europe PubMed Central |
| Popis: | Changes in the major component of renal cortical membranes as well as membrane fluidity and Na+, K+, ATPase activity have been studied in membranes from the renal cortex of rats with experimental liver cirrhosis, which show renal sodium and water retention, and in normal animals. Rats with cirrhosis of the liver show a decrease in cholesterol, phospholipid and protein content, without changes in cholesterol/phospholipid molar ratio. In addition there is a small decrease in 14:0 and 18:2 and an increase in 20:4 content, without differences in unsaturation degree. Membrane fluidity was decreased in renal membranes from cirrhotic rats when compared with normal ones. Na+, K+, ATPase activity was higher in cirrhotic than in normal renal membranes could be related with the changes in renal water and electrolyte changes shown by cirrhotic rats. |
| Databáze: | OpenAIRE |
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