Changes in biomarkers in equine synovial fluid two weeks after intra-articular hyaluronan treatment: a randomised double-blind clinical trial

Autor: Riitta-Mari Tulamo, Anna Hielm-Björkman, Kaisa Aaltonen, Tytti Niemelä, Satu Sankari
Přispěvatelé: Equine and Small Animal Medicine, Departments of Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Petbone – ortopedia, fysioterapia, kivunlievitys, Research Centre for Animal Welfare
Rok vydání: 2018
Předmět:
Cartilage
Articular
Male
PROSTAGLANDIN E-2
Lameness
Animal
Prostaglandin E2
medicine.medical_treatment
Substance P
413 Veterinary science
Gastroenterology
0403 veterinary science
chemistry.chemical_compound
0302 clinical medicine
Synovial Fluid
Hyaluronic acid
CARTILAGE-DERIVED BIOMARKERS
Hyaluronic Acid
Saline
IN-VIVO
Synovitis
lcsh:Veterinary medicine
04 agricultural and veterinary sciences
General Medicine
Placebo-controlled
3. Good health
medicine.anatomical_structure
POLYSULFATED GLYCOSAMINOGLYCAN
Biomarker (medicine)
Female
Research Article
medicine.medical_specialty
Non-animal stabilized hyaluronic acid (NASHA)
040301 veterinary sciences
Sodium hyaluronate
Clinical study
03 medical and health sciences
Polysulfated glycosaminoglycan
Internal medicine
White blood cell
medicine
Animals
Aggrecan chondroitin sulfate 846 epitope
Synovial fluid
Horses
Adverse effect
030203 arthritis & rheumatology
General Veterinary
business.industry
EXPERIMENTALLY-INDUCED OSTEOARTHRITIS
SODIUM HYALURONATE
ARTICULAR-CARTILAGE
SUBSTANCE-P
JOINT DISEASE
chemistry
lcsh:SF600-1100
Horse Diseases
Carboxypeptide of type II collagen
business
INFLAMMATORY MEDIATORS
Biomarkers
Zdroj: BMC Veterinary Research, Vol 14, Iss 1, Pp 1-9 (2018)
BMC Veterinary Research
ISSN: 1746-6148
DOI: 10.1186/s12917-018-1512-2
Popis: Background: Inflammatory and degenerative activity inside the joint can be studied in vivo via analysis of synovial fluid (SF) biomarkers, which are molecular markers of inflammatory processes and tissue turnover. The aim of this study was to investigate the response of selected biomarkers in the SF after an intra-articular (IA) high-molecular-weight non-animal stabilized hyaluronic acid (NASHA) treatment. Our hypothesis was that prostaglandin E-2 (PGE(2)), substance P, aggrecan chondroitin sulfate 846 epitope (CS846), and carboxypeptide of type II collagen (CPII) concentrations in SF would decrease more in the NASHA than in the placebo group. Twenty-eight clinically lame horses with positive responses to diagnostic IA anaesthesia of the metacarpophalangeal or metatarsophalangeal joints were randomized into treatment (n = 15) and control (n = 13) groups. After collection of baseline SF samples followed by IA diagnostic anaesthesia, horses in the treatment group received 3 ml of a NASHA product IA. Those in the placebo group received an equivalent volume of sterile 0.9% saline solution. The horses were re-evaluated and a second SF sample was obtained after a 2-week period. Results: CS846 concentration decreased in the NASHA group only (P = 0.010). Both PGE(2) and CPII concentrations decreased within the groups (PGE(2), P = 0.010 for the NASHA group; P = 0.027 for the placebo group; CPII, P
Databáze: OpenAIRE
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