Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF)
| Autor: | Yanjun Fu, Barbara Sennino, Donald M. McDonald, V Rogut, Clemens C. Cyran, Bundit Chaopathomkul, Michael F. Wendland, Robert C. Brasch, David M. Shames, Hans-Juergen Raatschen |
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| Rok vydání: | 2012 |
| Předmět: |
Gadolinium DTPA
Vascular Endothelial Growth Factor A Pathology medicine.medical_specialty Macromolecular Substances Contrast Media Vascular permeability Article Capillary Permeability Neovascularization Rats Nude chemistry.chemical_compound Cell Line Tumor Biomarkers Tumor medicine Animals Humans Radiology Nuclear Medicine and imaging Neovascularization Pathologic medicine.diagnostic_test business.industry Magnetic resonance imaging Neoplasms Experimental General Medicine Magnetic Resonance Imaging Neoplasm Proteins Rats Vascular endothelial growth factor Contrast medium Vascular endothelial growth factor A chemistry Dynamic contrast-enhanced MRI Immunohistochemistry Female medicine.symptom business |
| Zdroj: | European Journal of Radiology. 81:891-896 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2011.07.016 |
| Popis: | Purpose To correlate dynamic MRI assays of macromolecular endothelial permeability with microscopic area–density measurements of vascular endothelial growth factor (VEGF) in tumors. Methods and material This study compared tumor xenografts from two different human cancer cell lines, MDA-MB-231 tumors (n = 5), and MDA-MB-435 (n = 8), reported to express respectively higher and lower levels of VEGF. Dynamic MRI was enhanced by a prototype macromolecular contrast medium (MMCM), albumin-(Gd-DTPA)35. Quantitative estimates of tumor microvascular permeability (KPS; μl/min × 100 cm3), obtained using a two-compartment kinetic model, were correlated with immunohistochemical measurements of VEGF in each tumor. Results Mean KPS was 2.4 times greater in MDA-MB-231 tumors (KPS = 58 ± 30.9 μl/min × 100 cm3) than in MDA-MB-435 tumors (KPS = 24 ± 8.4 μl/min × 100 cm3) (p |
| Databáze: | OpenAIRE |
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