Brain accumulation of myo-inositol in the trisomy 16 mouse, an animal model of Down's syndrome
| Autor: | H U Shetty, Harold W. Holloway, Z Galdzicki, Larisa D. Acevedo |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Down syndrome Trisomy Biology Biochemistry Mice chemistry.chemical_compound Sugar Alcohols Cerebrospinal fluid Internal medicine medicine Animals Homeostasis Humans Inositol Molecular Biology Brain Trisomy 16 Cell Biology medicine.disease Diploidy Peripheral Mice Inbred C57BL carbohydrates (lipids) Disease Models Animal Endocrinology chemistry Immunology Female Down Syndrome Ploidy Research Article |
| Zdroj: | Biochemical Journal. 313:31-33 |
| ISSN: | 1470-8728 0264-6021 |
| DOI: | 10.1042/bj3130031 |
| Popis: | myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mouse. However, peripheral tissues showed no elevation. These results are consistent with the cerebrospinal fluid and plasma data reported previously on myo-inositol in Down's Syndrome subjects. |
| Databáze: | OpenAIRE |
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