Aminoglycoside trough levels in neonates
| Autor: | Milica Rankovic-Janevski, Niveska Bozinovic-Prekajski, Biljana Pejovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Trough (geology) lcsh:Medicine Gestational Age gentamicin Gastroenterology Pharmacokinetics Internal medicine amikacin medicine trough level Humans business.industry Body Weight Aminoglycoside lcsh:R Infant Newborn Gestational age General Medicine Anti-Bacterial Agents Amikacin Gestation Trough level Gentamicin Gentamicins neonate business medicine.drug |
| Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 138, Iss 1-2, Pp 50-55 (2010) |
| ISSN: | 0370-8179 |
| Popis: | Introduction. Drug safety depends on trough levels. Objective. Objective of the study was to measure gentamicin and amikacin trough levels in neonates and to identify risk groups by gestational and postnatal age. Methods. Gentamicin and amikacin were applied according to the clinical practice guidelines. Trough levels (mg/l) were deter- mined using fluorescence polarization immunoassay methodology. Target trough levels were 7 days. Results. Out of 163 neonates, 111 were receiving gentamicin and 52 amikacin. Mean amikacin trough level was 7.8?4.8 mg/l and, in group I 10.5?4.9 mg/l, which was above the target range and significantly higher than in group II (LSD, p |
| Databáze: | OpenAIRE |
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