Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers
| Autor: | Christiane S. Eberhardt, Paul-Henri Lambert, Maria Vono, Sylvain Lemeille, Dennis Christensen, Beatris Mastelic-Gavillet, Claire-Anne Siegrist, Floriane Auderset, Peter Andersen |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Antibody Formation/immunology T-Lymphocytes ddc:616.07 Antibodies Viral Inbred C57BL Mice 0302 clinical medicine Orthomyxoviridae Infections/immunology/virology Pregnancy germinal centers Gene expression Maternal-Fetal Exchange lcsh:QH301-705.5 Inbred BALB C B-Lymphocytes Mice Inbred BALB C Orthomyxoviridae/immunology biology Helper-Inducer/immunology Vaccination repertoire B-Lymphocytes/immunology T-Lymphocytes Helper-Inducer Orthomyxoviridae 3. Good health Antibodies/blood/immunology epitope masking medicine.anatomical_structure Female Antibody Offspring General Biochemistry Genetics and Molecular Biology Antibodies 03 medical and health sciences Germinal Center/immunology Orthomyxoviridae Infections medicine Animals Gene B cell Germinal center Maternal-Fetal Exchange/immunology Germinal Center Newborn neonates Mice Inbred C57BL 030104 developmental biology maternal antibodies Immunoglobulin class switching Immunization Animals Newborn lcsh:Biology (General) Immunology Antibody Formation biology.protein Viral/blood/immunology 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, Vol. 28, No 7 (2019) pp. 1773-1784.e5 Vono, M, Eberhardt, C S, Auderset, F, Mastelic-Gavillet, B, Lemeille, S, Christensen, D, Andersen, P, Lambert, P H & Siegrist, C A 2019, ' Maternal Antibodies Inhibit Neonatal and Infant Responses to Vaccination by Shaping the Early-Life B Cell Repertoire within Germinal Centers ', Cell Reports, vol. 28, no. 7, pp. 1773-1784.e5 . https://doi.org/10.1016/j.celrep.2019.07.047 Cell Reports, Vol 28, Iss 7, Pp 1773-1784.e5 (2019) |
| ISSN: | 2211-1247 |
| DOI: | 10.1016/j.celrep.2019.07.047 |
| Popis: | Summary: Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to vaccination. The mechanisms of this inhibition are still debated. Using murine early-life immunization models mimicking the condition prevailing in humans, we observed the induction of CD4-T, T follicular helper, and germinal center (GC) B cell responses even when early-life antibody responses were abrogated by MatAbs. GC B cells induced in the presence of MatAbs form GC structures and exhibit canonical GC changes in gene expression but fail to differentiate into plasma cells and/or memory B cells in a MatAb titer-dependent manner. Furthermore, GC B cells elicited in the presence or absence of MatAbs use different VH and Vk genes and show differences in genes associated with B cell differentiation and isotype switching. Thus, MatAbs do not prevent B cell activation but control the output of the GC reaction both quantitatively and qualitatively, shaping the antigen-specific B cell repertoire. : Maternal antibodies (MatAbs) protect offspring from infections but limit their vaccine responses through still poorly known mechanisms. Vono et al. report that MatAbs do not prevent B cell activation or germinal center formation but control plasma cell and memory B cell differentiation, shaping the long-term antigen-specific B cell repertoire. Keywords: immunization, maternal antibodies, neonates, repertoire, germinal centers, epitope masking |
| Databáze: | OpenAIRE |
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