Life events, cortisol and levels of prostate specific antigen: A story of synergism

Autor: Yori Gidron, Bibiana Fabre, Halina Grosman, Gabriela Berg, Viviana Mesch, Osvaldo Mazza, Carlos Nolazco
Přispěvatelé: Neuroprotection & Neuromodulation, Medicine and Pharmacy academic/administration
Rok vydání: 2011
Předmět:
Employment
Male
Hypothalamo-Hypophyseal System
medicine.medical_specialty
Hydrocortisone
Endocrinology
Diabetes and Metabolism
Pituitary-Adrenal System
cortisol
Body Mass Index
Life Change Events
Life events
Habits
Prostate cancer
chemistry.chemical_compound
Endocrinology
synergism
Internal medicine
medicine
Humans
Marriage
Triglycerides
Biological Psychiatry
Aged
Tumor marker
Cocarcinogenesis
PROSTATE SPECIFIC ANTIGEN
Endocrine and Autonomic Systems
Cholesterol
Cholesterol
HDL
Prostate
Prostatic Neoplasms
Cancer
Middle Aged
Prostate-Specific Antigen
medicine.disease
Psychiatry and Mental health
Prostate-specific antigen
medicine.anatomical_structure
Socioeconomic Factors
chemistry
Antigen
Disease Susceptibility
Psychology
Psychosocial
Body mass index
Stress
Psychological
Hypothalamic–pituitary–adrenal axis
Zdroj: Psychoneuroendocrinology. 36:874-880
ISSN: 0306-4530
DOI: 10.1016/j.psyneuen.2010.11.011
Popis: Background: Previous studies have tested the relationship between stressful life events (LE) and cancer onset, but inconsistent results have been found. One possibility is that the LE-cancer relation may depend on other biological factors pertinent to stress and cancer. Methods: This study examined the relationship between LE and prostate specific antigen (PSA) levels, a tumor marker, and whether cortisol mediates or moderates a LE-PSA relationship. During a voluntary screening for prostate cancer risk, 139 men (mean age = 57.3 years) were assessed with the Holmes and Rahe questionnaire about their LE during the past 1-5 years, and their PSA and serum cortisol levels were measured. Results: LE and cortisol alone were unrelated to PSA. However, statistically controlling for age, body mass index and the ratio of triglycerides to HDL cholesterol, we found evidence for a synergistic interaction between LE and cortisol. Among men with low cortisol, number of LE were inversely and significantly correlated with PSA (r = -0.265, p
Databáze: OpenAIRE
Externí odkaz: