IL-1β and the Intestinal Epithelial Tight Junction Barrier
Autor: | Thomas Y. Ma, Rana Al-Sadi, Lauren W. Kaminsky |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Therapeutic gene modulation
Myosin light-chain kinase Cell Membrane Permeability Junctional Adhesion Molecules NF-kappaB (NF-κB) Immunology Interleukin-1beta interleukin-1β (IL-1β) Review Occludin Models Biological Tight Junctions intestinal inflammation Immunology and Allergy Humans Intestinal Mucosa Transcription factor Myosin-Light-Chain Kinase myosin light chain kinase (MLCK) Tight junction microRNA Chemistry Epithelial Cells RC581-607 Cell biology Paracellular transport intestinal tight junction (TJ) barrier Tumor necrosis factor alpha Immunologic diseases. Allergy Signal transduction |
Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
ISSN: | 1664-3224 |
Popis: | The intestinal epithelial tight junction (TJ) barrier controls the paracellular permeation of contents from the intestinal lumen into the intestinal tissue and systemic circulation. A defective intestinal TJ barrier has been implicated as an important pathogenic factor in inflammatory diseases of the gut including Crohn’s disease, ulcerative colitis, necrotizing enterocolitis, and celiac disease. Previous studies have shown that pro-inflammatory cytokines, which are produced during intestinal inflammation, including interleukin-1β (IL-1β), tumor necrosis factor-α, and interferon-γ, have important intestinal TJ barrier-modulating actions. Recent studies have shown that the IL-1β-induced increase in intestinal TJ permeability is an important contributing factor of intestinal inflammation. The IL-1β-induced increase in intestinal TJ permeability is mediated by regulatory signaling pathways and activation of nuclear transcription factor nuclear factor-κB, myosin light chain kinase gene activation, and post-transcriptional occludin gene modulation by microRNA and contributes to the intestinal inflammatory process. In this review, the regulatory role of IL-1β on intestinal TJ barrier, the intracellular mechanisms that mediate the IL-1β modulation of intestinal TJ permeability, and the potential therapeutic targeting of the TJ barrier are discussed. |
Databáze: | OpenAIRE |
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