Long-Term Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infectiousness Among Three Immunocompromised Patients: From Prolonged Viral Shedding to SARS-CoV-2 Superinfection
| Autor: | Jean-Christophe Lucet, Hassan Tarhini, Diane Descamps, Christophe Rioux, Amélie Recoing, Quentin Le Hingrat, François-Xavier Lescure, Yazdan Yazdanpanah, Benoit Visseaux, Samuel Lebourgeois, Donia Bouzid, Mayda Rahi, Pascale Martres, Céleste Lambert, Antoine Bridier-Nahmias |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Isolation (health care) Viral culture business.industry medicine.disease_cause Virology Asymptomatic Serology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases Superinfection Epidemiology medicine Immunology and Allergy 030212 general & internal medicine Viral shedding medicine.symptom business Coronavirus |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/jiab075 |
| Popis: | Background Guidelines for stopping coronavirus disease 2019 patient isolation are mainly symptom-based, with isolation for 10 to 20 days depending on their condition. Methods In this study, we describe 3 deeply immunocompromised patients, each with different clinical evolutions. We observed (1) the patients’ epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3) viral mutations accumulated over time. Results Asymptomatic carriage, symptom resolution, or superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading to prolonged infectious viral shedding for several months. Conclusions Understanding underlying mechanisms and frequency of prolonged infectiousness is crucial to adapt current guidelines and strengthen the use of systematic polymerase chain reaction testing before stopping isolation in immunocompromised populations. |
| Databáze: | OpenAIRE |
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