Copper-catalyzed oxidative benzylic C(sp 3 )–H amination: direct synthesis of benzylic carbamates
| Autor: | Coline Boulanger, Jonathan Lusseau, Nivesh Kumar, Yannick Landais, Frédéric Robert, Shuai Liu, Govind Goroba Pawar, Raphaël Achou |
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| Přispěvatelé: | Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Carbamate
010405 organic chemistry Ligand Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry medicine.medical_treatment Metals and Alloys Substrate (chemistry) General Chemistry Oxidative phosphorylation 010402 general chemistry 01 natural sciences Medicinal chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Materials Chemistry Ceramics and Composites medicine Amine gas treating Diimine Amination |
| Zdroj: | Chemical Communications Chemical Communications, Royal Society of Chemistry, 2020, 56 (85), pp.13013-13016. ⟨10.1039/d0cc05226d⟩ |
| ISSN: | 1359-7345 1364-548X |
| DOI: | 10.1039/d0cc05226d⟩ |
| Popis: | International audience; A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of Cu(I)/diimine ligand in combination with NFSI ((PhSO2)2NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an amine source, direct leads to the C-N bond formation at benzylic position. The mild reaction conditions, and broad substrate scope make this transformation a useful method for a late-stage incorporation of the ibiquitous carbamate fragment onto hydrocarbons. |
| Databáze: | OpenAIRE |
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