Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children
| Autor: | Márcia Regina Vitolo, Silvia V Melo, Paula Dal Bó Campagnolo, Vanessa Suñé Mattevi, Grasiela Agnes, Silvana Almeida |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Taste food intake lcsh:QH426-470 Physiology Single-nucleotide polymorphism TAS1R3 gene Biology polymorphism 03 medical and health sciences lcsh:Genetics 030104 developmental biology 0302 clinical medicine TAS1R3 TAS1R2 Polymorphism (computer science) Taste receptor TAS1R2 gene Human and Medical Genetics Genotype Genetics SNP taste receptors Molecular Biology 030217 neurology & neurosurgery |
| Zdroj: | Genetics and Molecular Biology, Vol 40, Iss 2, Pp 415-420 (2017) Genetics and Molecular Biology, Volume: 40, Issue: 2, Pages: 415-420, Published: 11 MAY 2017 Genetics and Molecular Biology v.40 n.2 2017 Genetics and Molecular Biology Sociedade Brasileira de Genética (SBG) instacron:SBG |
| ISSN: | 1678-4685 |
| Popis: | Taste perception plays a key role in determining individual food preferences and dietary habits and may influence nutritional status. This study aimed to investigate the association of TAS1R2 (Ile191Val - rs35874116) and TAS1R3 (-1266 C/T - rs35744813) variants with food intake and nutritional status in children followed from birth until 7.7 years old. The nutritional status and food intake data of 312 children were collected at three developmental stages (1, 3.9 and 7.7 years old). DNA was extracted from blood samples and the polymorphisms were analyzed by real-time polymerase chain reactions (qPCR) using hydrolysis probes as the detection method. Food intake and nutritional status were compared among individuals with different single nucleotide polymorphism (SNP) genotypes. At 3.9 years old, children homozygous (Val/Val) for the TAS1R2 Ile191Val polymorphism ingested less sugar and sugar-dense foods than children who were *Ile carriers. This finding demonstrated that a genetic variant of the T1R2 taste receptor is associated with the intake of different amounts of high sugar-content foods in childhood. This association may provide new perspectives for studying dietary patterns and nutritional status in childhood. |
| Databáze: | OpenAIRE |
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