Healing of polytetrafluoroethylene arterial grafts is influenced by graft porosity
| Autor: | Peter A. Schneider, Thomas R. Kirkman, Michael A. Golden, S. R. Hanson, Alexander W. Clowes |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Endothelium Surface Properties Anastomosis Muscle Smooth Vascular chemistry.chemical_compound Smooth muscle Animals Medicine Porosity Polytetrafluoroethylene Wound Healing business.industry Anatomy Blood Vessel Prosthesis Arterial grafts Endothelial stem cell medicine.anatomical_structure chemistry Microscopy Electron Scanning Autoradiography Surgery Endothelium Vascular Cardiology and Cardiovascular Medicine business Papio Biomedical engineering Artery |
| Zdroj: | Journal of Vascular Surgery. 11:838-845 |
| ISSN: | 0741-5214 |
| Popis: | The importance of porosity in synthetic arterial graft healing has not been adequately defined. To determine the effect of porosity on graft healing, we measured the extent of cellular response at late times in 4 mm internal diameter polytetrafluoroethylene grafts of varying porosity (between 10 and 90 μm internodal distance) inserted into the arterial system of baboons. After 1 and 3 months the grafts were retrieved and examined for endothelial coverage, intimal thickening, and endothelial cell and smooth muscle cell proliferation. The pattern of intimal healing with endothelial cells and smooth muscle cells was only related to porosity in the sense that there was an abrupt switch in the pattern of healing as porosity was increased from 30 to 60 μm. In low porosity grafts (10 and 30 μm internodal distances) endothelial coverage of the luminal surface was incomplete and, along with intimal thickening, was limited to graft near the anastomosis. In high porosity grafts (60 and 90 μm internodal distances) luminal endothelial coverage was complete, and intimal thickening was uniformly distributed throughout the graft. The highest porosity graft studied (90 μm) developed areas of focal loss of endothelial cells at late time periods. In this limited series there does appear to be an optimal porosity for polytetrafluoroethylene grafts near 60 μm, since 10 and 30 μm grafts fail to achieve luminal endothelial cell coverage, and 90 μm grafts exhibit instability of the intima with focal endothelial cell loss. (J VASC SURG 1990;11:838-45.) |
| Databáze: | OpenAIRE |
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