Effect of Inflammatory Bowel Disease–Related Characteristics and Treatment Interventions on Cardiovascular Disease Incidence
| Autor: | Jason Schairer, Waseem Imam, Hiba Hadid, Sudeep Thapa, Syed-Mohammed Jafri |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Anti-Inflammatory Agents Risk Assessment Inflammatory bowel disease Coronary artery disease Internal medicine Azathioprine medicine Humans Aged Retrospective Studies Crohn's disease Framingham Risk Score Mercaptopurine Tumor Necrosis Factor-alpha business.industry Incidence Incidence (epidemiology) Case-control study Retrospective cohort study General Medicine Odds ratio Middle Aged Inflammatory Bowel Diseases medicine.disease Surgery Logistic Models Cardiovascular Diseases Case-Control Studies Female business |
| Zdroj: | The American Journal of the Medical Sciences. 350:175-180 |
| ISSN: | 0002-9629 |
| Popis: | Background An association between inflammatory bowel disease (IBD) and cardiovascular diseases has been shown in multiple studies. However, little is known about the effect of IBD-related characteristics on cardiovascular events. Methods The authors conducted a retrospective, nested case-control study of IBD patients who presented to the institution from 2000 to 2004, allowing for a 10-year follow-up period. One hundred eleven patients who developed cardiovascular events (cases) and 222 patients who did not develop cardiovascular events (cases) were included in the study after matching for Framingham cardiovascular risk score (2008). Relationships between predictor variables and cardiovascular outcome were assessed by conditional logistic regression. Results The cases and controls were similar in age, gender, smoking and cholesterol level. There was no difference in disease subtype (ulcerative colitis or Crohn's disease). On conditional logistic regression, thiopurine treatment (odds ratio [OR]: 0.42, 95% confidence interval [CI]: 0.19–0.87; P = 0.02) was associated with decreased cardiovascular events and tumor necrosis factor alpha antagonist use (OR: 2.63, 95% CI: 1.49–4.63; P = 0.001) was associated with increased cardiovascular events. Although not statistically significant, disease-related surgery (OR: 0.57, 95% CI: 0.32–1.02; P = 0.06) was associated with decreased cardiovascular events and disease-related hospitalization (OR: 1.58, 95% CI: 0.96–2.57; P = 0.07) was associated with increased incidence of cardiovascular disorders. Conclusions The authors observed decreased incidence of cardiovascular diseases in patients with IBD who were treated with thiopurines and increased incidence of cardiovascular outcomes among patients treated with tumor necrosis factor alpha antagonist. |
| Databáze: | OpenAIRE |
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