Evidence for Genetic Associations between Asthma, Atopy, and Bronchial Hyperresponsiveness
| Autor: | Carol J. Mayne, Jane R. Clarke, John B. Carlin, Colin F. Robertson, David Clayton, Mark A. Jenkins, Diane P Holst, M Dalton, John L. Hopper |
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| Rok vydání: | 2000 |
| Předmět: |
Hypersensitivity
Immediate Male Pulmonary and Respiratory Medicine Adolescent Victoria Population Physiology Critical Care and Intensive Care Medicine Bronchial Provocation Tests Atopy Surveys and Questionnaires Diseases in Twins Odds Ratio Twins Dizygotic medicine Humans Child education Skin Tests Asthma education.field_of_study business.industry Twins Monozygotic Odds ratio medicine.disease Confidence interval Hypertonic saline Bronchial hyperresponsiveness Immunology Hay fever Female Bronchial Hyperreactivity business |
| Zdroj: | Scopus-Elsevier ResearcherID |
| ISSN: | 1535-4970 1073-449X |
| DOI: | 10.1164/ajrccm.162.6.9904057 |
| Popis: | We measured asthma in the last 12 mo, diagnosed by a respiratory physician at interview; atopy, defined by a positive skin prick test to any of eight common allergens; and bronchial hyperresponsiveness (BHR) to hypertonic saline, in 381 twin pairs aged 8 to 18 yr selected from the Australian Twin Registry-183 monozygous (MZ) and 198 dizygous (DZ). The associations between twins, as measured by an odds ratio, were greater in MZ pairs compared with DZ pairs for asthma: 25.6 (95% confidence interval 11.3- 57.8) versus 1.9 (1.0-3. 5); atopy: 14.6 (7.1-30.1) versus 2.5 (1.4- 4.5); and BHR: 14.1 (6. 4-31.0) versus 4.2 (2.1-8.6) (all p0.002). The associations between each pair of traits within an individual were slightly greater than the association between one trait in a twin and the other trait in the cotwin (cross-trait cross-pair) in MZ pairs. Further, the associations in MZ pairs were greater than in DZ pairs (p0.05). Under the assumptions of the classic twin model, these data suggest that the strong cross-sectional associations between these three traits are due to an overlap between the genetic factors involved in each of these three traits. |
| Databáze: | OpenAIRE |
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