Pemphigus erythematosus relapse associated with atorvastatin intake
| Autor: | Ada Lo Schiavo, Francesca Romano, Roberto Cozzi, Rosa Puca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Atorvastatin Pharmaceutical Science Case Report autoimmune disease statins Recurrence Drug Discovery Lupus Erythematosus Cutaneous Medicine pemphigus erythematosus Humans Pyrroles cardiovascular diseases Adverse effect Myositis Pharmacology Autoimmune disease Lupus erythematosus treatment business.industry pathogenesis Pemphigus erythematosus Autoantibody nutritional and metabolic diseases Middle Aged medicine.disease Pemphigus Heptanoic Acids Immunology lipids (amino acids peptides and proteins) business medicine.drug |
| Zdroj: | Drug Design, Development and Therapy |
| ISSN: | 1177-8881 |
| Popis: | Statins, also known as 3-hydroxy-3-methylglutaril-CoA reductase inhibitors, are well-tolerated drugs used for prevention of atherosclerosis and cardiovascular events. Although they are generally considered safe, some serious adverse effects, such as myositis, myopathy, and rhabdomyolysis can rarely occur. Furthermore, recent data from long-term follow-up on patients who have been taking statins for a long period of time suggest that prolonged exposure to statins may trigger autoimmune reactions. The exact mechanism of statin-induced autoimmune reactions is unclear. Statins, as proapoptotic agents, release nuclear antigen into the circulation and may induce the production of pathogenic autoantibodies. Herein we report the case of a 70 year-old man who developed a relapse of pemphigus erythematosus, a syndrome with features of both lupus erythematosus and pemphigus, after atorvastatin intake. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|