Dependence of kidney morphogenesis on the expression of nerve growth factor receptor
| Autor: | Anne Vaahtokari, Urmas Arumäe, Irma Thesleff, Mart Saarma, Kirsi Sainio, Jaan Palgi, Hannu Sariola, Alexander Karavanov |
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| Rok vydání: | 1991 |
| Předmět: |
Nervous system
medicine.medical_specialty Molecular Sequence Data Gene Expression Receptors Cell Surface Receptors Nerve Growth Factor Kidney PC12 Cells Kidney morphogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Nerve Growth Factors RNA Messenger Binding site 030304 developmental biology 0303 health sciences Multidisciplinary biology Base Sequence urogenital system Oligonucleotide Embryogenesis Oligonucleotides Antisense Embryo Mammalian Embryonic stem cell 3. Good health Cell biology Rats Endocrinology medicine.anatomical_structure biology.protein 030217 neurology & neurosurgery Function (biology) Neurotrophin |
| Zdroj: | Science (New York, N.Y.). 254(5031) |
| ISSN: | 0036-8075 |
| Popis: | Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors. Although NGFR has been found in several embryonic tissues outside the nervous system, the function of NGFR in embryogenesis of non-neuronal organs remains unknown. NGFR is transiently synthesized by embryonic rat kidney and disappears from nephrons upon their terminal differentiation. Anti-sense oligonucleotide inhibition of NGFR expression inhibits kidney morphogenesis. Therefore, NGFR is required not only for development of the nervous system, but also for differentiation of the kidney tubules. |
| Databáze: | OpenAIRE |
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