Gaps and fragmentation of the superficial cortex in the abdominal and pelvic lymph nodes of elderly Japanese
| Autor: | Izumi Taniguchi, Masanori Suzuki, Hirofumi Ichikawa, Akiyasu Sato, Gen Murakami, Daisuke Fujiwara, Shin-ichi Nawata |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Cord Efferent Pelvis Japan Cadaver Cortex (anatomy) Abdomen medicine Humans Sinus (anatomy) Aged Aged 80 and over business.industry General Medicine Anatomy medicine.anatomical_structure Lymphatic system Female Lymph Nodes Lymph business Superficial Lymph Node |
| Zdroj: | Anatomical Science International. 78:211-222 |
| ISSN: | 1447-073X 0022-7722 |
| DOI: | 10.1046/j.0022-7722.2003.00057.x |
| Popis: | Gaps and fragmentation of the superficial lymph node cortex are considered to provide intranodal shunt flow between the afferent and efferent vessels. Using serial sections of 205 nodes obtained from 27 donated cadavers more than 70 years of age, we examined the histological architecture of the abdominal and pelvic nodes in elderly Japanese. Secondary follicles were rare in the specimens. Cortex gaps were, to a greater or lesser degree, found in all nodes. We classified these nodes into three types according to how often the gap occurred. Type 1 nodes, with a relatively complete shield for the afferent lymph, were most frequently found in gastric nodes, whereas type 3 nodes, with numerous gaps, were often observed in the colic, para-aortic and pelvic nodes. The type 3 nodes showed a specific architecture characterized by a fragmented superficial cortex, three-dimensionally assembled cords and a common sinus between them. Primary follicles were located in the assembled cord structures as well as at the superficial cortex. Irrespective of the type, B and T lymphocyte areas were intermingled in the cortex-like areas. The present results reveal region-specific histological heterogeneity in aged human visceral nodes. Due to increased surface areas, the type 3 architecture seemed to accelerate systemic immunity rather than act as a local barrier in the para-aortic and pelvic nodes, which are located centrally along the lymphatic drainage routes. However, thick trabeculae often seemed to develop in the type 3 sinus to decrease nodal function with aging. |
| Databáze: | OpenAIRE |
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