Design and synthesis of novel 2-phenylaminopyrimidine (PAP) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells

Autor:	Shi-Liang Yin, Yongkui Jing, Jian Wang, Jinhua Dong, Chang Sheng
Rok vydání:	2009
Předmět:	antiproliferative activity Fusion Proteins bcr-abl Pharmaceutical Science Antineoplastic Agents STI-571 Piperazines Article Analytical Chemistry lcsh:QD241-441 Myelogenous chemistry.chemical_compound lcsh:Organic chemistry Cell Line Tumor Leukemia Myelogenous Chronic BCR-ABL Positive Drug Discovery medicine Humans Physical and Theoretical Chemistry Protein Kinase Inhibitors Cell Proliferation Acrylamides Chemistry Organic Chemistry 2-Phenylaminopyrimidine (PAP) derivative Myeloid leukemia Protein-Tyrosine Kinases medicine.disease Virology Fusion protein Leukemia Imatinib mesylate Pyrimidines Chemistry (miscellaneous) Cell culture Acrylamide Drug Design Benzamides Cancer research Imatinib Mesylate Molecular Medicine K562 cells
Zdroj:	Molecules Molecules; Volume 14; Issue 10; Pages: 4166-4179 Molecules, Vol 14, Iss 10, Pp 4166-4179 (2009)
ISSN:	1420-3049
Popis:	A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acryla- mide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633cc93a99ff396f425975c7beaa7ab3 https://pubmed.ncbi.nlm.nih.gov/19924055 Zobrazit plný text záznamu Plný text ve formátu PDF