Prevalence of extended-spectrum beta-lactamase-producing enterobacterial urinary infections and associated risk factors in small children of Garoua, Northern Cameroon

Autor: Hermann Landry Munshili Njifon, Brunel Wanda Mbiakop, Elias Nukenine Nchiwan, Karyom Djim-Adjim-Ngana, Tania Crucitti, Leila Aïcha Oumar, Louis Deweerdt, Nicolas Njintang Yanou
Rok vydání: 2019
Předmět:
Male
medicine.medical_specialty
Microbiological culture
Klebsiella pneumoniae
medicine.drug_class
medicine.medical_treatment
030231 tropical medicine
Antibiotics
Urine
Microbial Sensitivity Tests
Urinalysis
beta-Lactamases
antibiotics
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Drug Resistance
Multiple
Bacterial
Epidemiology
synergy test
Bacteriology
Prevalence
Medicine
Humans
030212 general & internal medicine
Cameroon
Age of Onset
biology
business.industry
Public health
Research
Age Factors
Enterobacteriaceae Infections
Infant
General Medicine
biology.organism_classification
bacterial infections and mycoses
Anti-Bacterial Agents
Cross-Sectional Studies
Urinary infection
enterobacteria
Child
Preschool
Urinary Tract Infections
Beta-lactamase
Female
business
Zdroj: The Pan African Medical Journal
Pan African Medical Journal; Vol. 36 No. 1 (2020)
ISSN: 1937-8688
Popis: Introduction:the emergence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (E-ESBLs) is currently a major public health problem in the world and, in particular, in developing countries. In Cameroon, data on E-ESBLs are rare, especially in Garoua and in the northern region of the country. The objective of this study is to document the epidemiology of E-ESBL infections in small children and to explore their associations with possible risk factors. Methods:this was a cross-sectional, descriptive study conducted from June 14 to September 30, 2018, including small children with suspected urinary tract infections (UTI) attending the outpatient pediatric departments of two health facilities in the city of Garoua. Urine samples were analyzed at the Bacteriology Laboratory of the Pasteur Center of Cameroon, Annex Garoua. Bacterial culture was carried out on Bio-Rad UriSelect® chromogenic agar and the identification was confirmed by bioMérieux API 20E. The antibiotic susceptibility was determined using the bioMérieux ATB UR gallery and the ESBL phenotype was detected by the double disk synergy method according to the CA-SFM 2013 recommendations. The data was analyzed with the R Statistical Software version 2.15.2. Results:a total of 57 urine samples were collected from children aged from one month to two years, 37 boys and 20 girls. Bacteria were detected by culture in 20 samples:Escherichia coliwas the most frequently (75 %) isolated species followed byKlebsiella pneumoniae(25%). More than half of the infected samples (55%) contained E-ESBL. The presence of an ESBL was significantly associated with previous antibiotic intake up to 3 months prior current UTI (p=0.01664). The E-ESBL strains showed co-resistance to different antibiotics. Conclusion:this study reveals the important dissemination of E-ESBLs among small children in the community and a high rate of co-resistance to the different antibiotic families commonly used.
Databáze: OpenAIRE
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