The Sea Lamprey as an Etiological Model for Biliary Atresia
| Autor: | Yu Wen Chung-Davidson, Weiming Li, Chu Yin Yeh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.medical_treatment Intrahepatic bile ducts lcsh:Medicine Review Article Biology Liver transplantation General Biochemistry Genetics and Molecular Biology Cholestasis Fibrosis Biliary atresia Biliary Atresia medicine Animals Humans Petromyzon General Immunology and Microbiology Lamprey lcsh:R Infant General Medicine medicine.disease biology.organism_classification Liver Transplantation Disease Models Animal Bile Ducts Intrahepatic Liver Etiology Steatohepatitis human activities |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2015 (2015) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Biliary atresia (BA) is a progressive, inflammatory, and fibrosclerosing cholangiopathy in infants that results in obstruction of both extrahepatic and intrahepatic bile ducts. It is the most common cause for pediatric liver transplantation. In contrast, the sea lamprey undergoes developmental BA with transient cholestasis and fibrosis during metamorphosis, but emerges as a fecund adult with steatohepatitis and fibrosis in the liver. In this paper, we present new histological evidence and compare the sea lamprey to existing animal models to highlight the advantages and possible limitations of using the sea lamprey to study the etiology and compensatory mechanisms of BA and other liver diseases. Understanding the signaling factors and genetic networks underlying lamprey BA can provide insights into BA etiology and possible targets to prevent biliary degeneration and to clear fibrosis. In addition, information from lamprey BA can be used to develop adjunct treatments for patients awaiting or receiving surgical treatments. Furthermore, the cholestatic adult lamprey has unique adaptive mechanisms that can be used to explore potential treatments for cholestasis and nonalcoholic steatohepatitis (NASH). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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