Ago-allosteric modulators of human glucagon-like peptide 2 receptor

Autor:	Takaki Kagaya, Misako Watanabe, Junichi Nagakawa, Hironori Fukumoto, Kappei Tsukahara, Koichiro Koyama, Shuichi Suzuki, Kazuto Yamazaki, Mika Aoki, Daisuke Iida, Kazuma Takase, Hiroki Terauchi, Tohru Arai, Takashi Seiki
Rok vydání:	2012
Předmět:	Agonist endocrine system medicine.drug_class Clinical Biochemistry Allosteric regulation Pharmaceutical Science Peptide Thiophenes Biochemistry Benzoates Structure-Activity Relationship Drug Discovery medicine Receptors Glucagon Structure–activity relationship Humans Receptor Molecular Biology Glucagon-like peptide 1 receptor G protein-coupled receptor chemistry.chemical_classification Dose-Response Relationship Drug Molecular Structure digestive oral and skin physiology Organic Chemistry chemistry Glucagon-Like Peptide-2 Receptor Molecular Medicine hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 22(19)
ISSN:	1464-3405
Popis:	Glucagon-like peptide 2 (GLP-2) is an intestinotropic peptide that binds to GLP-2 receptor (GLP-2R), a class-B G protein-coupled receptor (GPCR). Few synthetic agonists have been reported so far for class-B GPCRs. Here, we report the first scaffold compounds of ago-allosteric modulators for human GLP-2R, derived from methyl 2-{[(2Z)-2-(2,5-dichlorothiophen-3-yl)-2-(hydroxyimino)ethyl]sulfanyl}benzoate (compound 1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633a4500ac37ce8e6b7aa2e11c3b7bf9 https://pubmed.ncbi.nlm.nih.gov/22944117 Zobrazit plný text záznamu Full Text from ScienceDirect