Correlations Between the Density of Tryptase Positive Mast Cells (DMCT) and that of New Blood Vessels (CD105+) in Patients with Gastric Cancer

Autor: Alexandra Bastian, Bianca Archip, Cristiana Popp, Mihai Rimbas, Liana Sticlaru, Eliza Gramadă, R Mateescu, Gianina Micu, G. Pop., Coralia Bleotu, Florica Stăniceanu
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Pathology
Angiogenesis
mast cells
Neovascularization
0302 clinical medicine
Risk Factors
Internal medicine
Neovascularization
Pathologic
biology
Endoglin
Middle Aged
Prognosis
Mast cell
medicine.anatomical_structure
030220 oncology & carcinogenesis
Immunohistochemistry
Female
medicine.symptom
Adult
medicine.medical_specialty
tryptase
Receptors
Cell Surface
Tryptase
Adenocarcinoma
Sensitivity and Specificity
Helicobacter Infections
03 medical and health sciences
Antigen
Antigens
CD
Gastrectomy
Predictive Value of Tests
Stomach Neoplasms
Biomarkers
Tumor
medicine
Humans
Aged
Neoplasm Staging
Retrospective Studies
Helicobacter pylori
business.industry
gastric cancer
Chymase
helicobacter pylori infection
new vessel density
RC31-1245
030104 developmental biology
Case-Control Studies
biology.protein
Tryptases
business
Zdroj: Romanian Journal of Internal Medicine, Vol 54, Iss 2, Pp 113-120 (2016)
ISSN: 2501-062X
DOI: 10.1515/rjim-2016-0016
Popis: Mast cells proteases, tryptase and chymase are directly involved in the growth and progression of solid tumors due to their important role in tumor angiogenesis. We examined the density of tryptase positive mast cells and the mean density of new blood vessels in gastric malignant tumors of patients with and without Helicobacter pylori infection, using immunohistochemical staining for tryptase (for mast cells) and CD 105 (for new vessels). Tryptase and CD 105 expression was detected in gastrectomy specimens. In this study, mast cell density correlates with angiogenesis and the growth and progression of gastric cancer. It also shows that the participation of Helicobacter pylori infection in the growth and progress of gastric neoplasia is due to an increase of peritumoral angiogenesis, with subsequent local and distant tumor spread and perivascular growth, but without perineural and nodal involvement.
Databáze: OpenAIRE
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