A theoretical model to characterize the drug release behavior of drug-eluting stents with durable polymer matrix coating
| Autor: | Hugh Q. Zhao, Syed F. A. Hossainy, Dudley Jayasinghe, Lewis B. Schwartz |
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| Rok vydání: | 2011 |
| Předmět: |
Drug
Materials science media_common.quotation_subject medicine.medical_treatment Sus scrofa Biomedical Engineering engineering.material Models Biological Polyethylene Glycols Biomaterials Diffusion Coating Restenosis Coated Materials Biocompatible In vivo medicine Animals Everolimus media_common Sirolimus Experimental drug Metals and Alloys Drug-Eluting Stents Arteries medicine.disease Controlled release Drug-eluting stent Polyvinyl Alcohol Drug delivery Ceramics and Composites engineering Biomedical engineering |
| Zdroj: | Journal of biomedical materials research. Part A. 100(1) |
| ISSN: | 1552-4965 |
| Popis: | The time-dependent local drug delivery from drug-eluting stents (DES) plays a critical role in reducing restenosis in intravascular stenting. To better understand the basic mechanism of drug release for certain polymer-drug-coated DES platforms, a cylindrical diffusion model was applied successfully to quantitatively describe the experimental drug release data of Dynalink-E in vitro and in vivo. The results showed that the profiles of Dynalink-E everolimus release could be controlled by such characteristic parameters as coating thickness and diffusion coefficient. The model could be used to quantitatively characterize the drug release profiles and IVIV correlations. |
| Databáze: | OpenAIRE |
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