Nanoemulsifying drug delivery system to improve the bioavailability of piroxicam
| Autor: | Thanaa Mohamed Borg, Abd El-Gawad, Amira Motawea, Manal Tarshoby |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Drug
Surface Properties Drug Compounding media_common.quotation_subject Administration Oral Biological Availability Pharmaceutical Science 02 engineering and technology Piroxicam 030226 pharmacology & pharmacy Surface-Active Agents 03 medical and health sciences 0302 clinical medicine Microscopy Electron Transmission Pharmacokinetics medicine Humans Plant Oils Dissolution testing Particle Size Solubility Dissolution media_common Drug Carriers Chromatography Dose-Response Relationship Drug Chemistry Anti-Inflammatory Agents Non-Steroidal General Medicine 021001 nanoscience & nanotechnology Soybean Oil Bioavailability Area Under Curve Drug delivery Coconut Oil Nanoparticles Emulsions 0210 nano-technology Tablets medicine.drug |
| Zdroj: | Pharmaceutical Development and Technology. 22:445-456 |
| ISSN: | 1097-9867 1083-7450 |
| DOI: | 10.1080/10837450.2016.1231810 |
| Popis: | The aim of this study is to develop and characterize self-nanoemulsifying drug delivery system (SNEDDS) of piroxicam in liquid and solid forms to improve its dissolution, absorption and therapeutic efficacy.The generation of liquid SNEDDS (L-SNEDDS) was composed of soybean or coconut oil/Tween 80/Transcutol HP (12/80/8%w/w) and it was selected as the optimized formulation based on the solubility study and pseudo-ternary phase diagram. Optimized L-SNEDDS and liquid supersaturatable SNEDDS (L-sSNEDDS) preparations were then adsorbed onto adsorbents and formulated as directly compressed tablets.The improved drug dissolution rate in the solid supersaturatable preparation (S-sSNEDDS) may be due to the formation of a nanoemulsion and the presence of drug in an amorphous state with hydrogen bond interaction between the drug and SNEDDS components. In vivo pharmacokinetic studies on eight healthy human volunteers showed a significant improvement in the oral bioavailability of piroxicam from S-sSNEDDS (F12) compared with both the pure drug (PP) and its commercial product (FeldeneThe obtained results ratify that S-sSNEDDS is a promising drug delivery system to enhance the oral bioavailability of piroxicam. |
| Databáze: | OpenAIRE |
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