The benefit of chronic graft-versus-host disease in patients with acute myeloid leukemia relapsed after allogeneic stem cell transplantation
| Autor: | Chunrong Yin, Jianmin Yang, Ziwei Wang, Jiong Hu, Weiping Zhang, Xianmin Song, Xiong Ni, Xiaoxia Hu, Jianmin Wang, Huiying Qiu, Wei Tang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Graft vs Host Disease Graft vs Leukemia Effect Gastroenterology Disease-Free Survival Donor lymphocyte infusion 03 medical and health sciences 0302 clinical medicine Recurrence hemic and lymphatic diseases Internal medicine medicine Humans Cumulative incidence In patient Retrospective Studies Hematology business.industry Incidence Hematopoietic Stem Cell Transplantation Myeloid leukemia General Medicine Middle Aged medicine.disease Survival Rate Transplantation Leukemia Myeloid Acute Graft-versus-host disease Lymphocyte Transfusion 030220 oncology & carcinogenesis Chronic Disease Female Stem cell business Follow-Up Studies 030215 immunology |
| Zdroj: | Annals of Hematology. 98:1765-1773 |
| ISSN: | 1432-0584 0939-5555 |
| Popis: | To investigate the effect of chronic graft-versus-host disease (cGVHD) on the outcomes of acute myeloid leukemia (AML) patients who relapsed after allogenic hematopoietic cell transplantation, we performed a retrospective analysis on 218 patients with a median follow-up of 21.4 (3.4–179.6) months. A total of 103 patients developed cGVHD, with a 2-year cumulative incidence of 48.9% (95% CI 42.1–55.7%). The estimated 3-year overall survival was 85.7% (95% CI 75.7–95.7%), 48.8% (95% CI 31.7–66.0%), and 54.1% (95% CI 44.3–63.8%) for patients with limited cGVHD, extensive cGVHD, and without cGVHD (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink