SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia

Autor:	Liu, Yumei, Shao, Zonghong, Wang, Huaquan
Rok vydání:	2022
Předmět:	COVID-19 Vaccines SARS-CoV-2 SARS-CoV-2 vaccine Antibody against platelet factor 4 COVID-19 Humans Adenoviral vector Thrombosis Hematology Short Review Thrombocytopenia
Zdroj:	Thrombosis Research
ISSN:	0049-3848
DOI:	10.1016/j.thromres.2021.12.002
Popis:	SARS-CoV-2 vaccines have been carefully developed and significantly alleviate the global pandemic. However, a rare but severe complication after vaccination of adenoviral vector vaccines has attracted worldwide attention. It is characterized by thrombosis at unusual sites (often cerebral or abdominal), thrombocytopenia, and the presence of antibodies against platelet factor 4 (PF4), termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Its pathogenesis is similar to that of heparin-induced thrombocytopenia (HIT). VITT progresses rapidly and has a high mortality rate. Clinicians and the public should raise their vigilance to this disease so that accurate and timely treatment is provided.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6334d03e069fe617c05ad2243b2b293d https://doi.org/10.1016/j.thromres.2021.12.002 Zobrazit plný text záznamu Full Text from ScienceDirect