Autoantibodies against the -adrenergic receptor in human myocarditis and dilated cardiomyopathy: -adrenergic agonism without desensitization
| Autor: | G. Wallukat, K. Kowal, A. Förster, A. Wollenberger, M. Morwinski, V. Boewer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Cardiomyopathy
Dilated medicine.medical_specialty Myocarditis Adrenergic beta-Antagonists Propranolol Desensitization (telecommunications) Heart Rate Internal medicine Receptors Adrenergic beta medicine Adrenergic antagonist Animals Humans Cells Cultured Autoantibodies Metoprolol business.industry Myocardium Hypertrophic cardiomyopathy Dilated cardiomyopathy medicine.disease Rats Endocrinology Desensitization Immunologic Bisoprolol gamma-Globulins Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | European Heart Journal. 12:178-181 |
| ISSN: | 1522-9645 0195-668X |
| DOI: | 10.1093/eurheartj/12.suppl_d.178 |
| Popis: | The serum of patients with myocarditis and dilated cardiomyopathy contains immunoglobulins capable of causing in vitro acceleration of beating of neonatal rat heart myocytes. This effect is stereoselectively inhibited by (-)-propranolol and is inhibited also by the beta 1-selective adrenergic antagonists, bisoprolol and metoprolol. This effect is not reversed by washing and continues unabated for at least 24 h. |
| Databáze: | OpenAIRE |
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