Tissue Engineering Strategies for Retina Regeneration
| Autor: | Mark S. Humayun, Kahini H. Patel, Magdalene J. Seiler, Deepthi S. Rajendran Nair, Vinoy Thomas, Juan Carlos Martinez Camarillo, Biju B. Thomas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
retinal pigment epithelium Regenerative Medicine Eye lcsh:Technology lcsh:Chemistry 0302 clinical medicine Tissue engineering Stem Cell Research - Nonembryonic - Human General Materials Science Induced pluripotent stem cell Instrumentation lcsh:QH301-705.5 Retinal regeneration Fluid Flow and Transfer Processes retinal degenerative diseases General Engineering lcsh:QC1-999 Computer Science Applications Cell biology medicine.anatomical_structure tissue engineering Stem cell Biotechnology Adult stem cell biomaterials Bioengineering 03 medical and health sciences stem cells medicine Eye Disease and Disorders of Vision age-related macular degeneration Transplantation Retina Retinal pigment epithelium Stem Cell Research - Induced Pluripotent Stem Cell 5.2 Cellular and gene therapies business.industry lcsh:T Process Chemistry and Technology Neurosciences Stem Cell Research 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 030221 ophthalmology & optometry business lcsh:Engineering (General). Civil engineering (General) lcsh:Physics |
| Zdroj: | Applied Sciences, Vol 11, Iss 2154, p 2154 (2021) Applied Sciences (Switzerland), vol 11, iss 5 Applied sciences (Basel, Switzerland), vol 11, iss 5 |
| ISSN: | 2076-3417 |
| Popis: | The retina is a complex and fragile photosensitive part of the central nervous system which is prone to degenerative diseases leading to permanent vision loss. No proven treatment strategies exist to treat or reverse the degenerative conditions. Recent investigations demonstrate that cell transplantation therapies to replace the dysfunctional retinal pigment epithelial (RPE) cells and or the degenerating photoreceptors (PRs) are viable options to restore vision. Pluripotent stem cells, retinal progenitor cells, and somatic stem cells are the main cell sources used for cell transplantation therapies. The success of retinal transplantation based on cell suspension injection is hindered by limited cell survival and lack of cellular integration. Recent advances in material science helped to develop strategies to grow cells as intact monolayers or as sheets on biomaterial scaffolds for transplantation into the eyes. Such implants are found to be more promising than the bolus injection approach. Tissue engineering techniques are specifically designed to construct biodegradable or non-degradable polymer scaffolds to grow cells as a monolayer and construct implantable grafts. The engineered cell construct along with the extracellular matrix formed, can hold the cells in place to enable easy survival, better integration, and improved visual function. This article reviews the advances in the use of scaffolds for transplantation studies in animal models and their application in current clinical trials. |
| Databáze: | OpenAIRE |
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