Sepsis in Solid-Organ Transplant Patients
| Autor: | Antônio Tonete Bafi, Flávio Geraldo Rezende Freitas, Daniere Yurie Vieira Tomotani |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation medicine.drug_class Antibiotics Population 030230 surgery Critical Care and Intensive Care Medicine Organ transplantation Sepsis 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Leukocytosis Intensive care medicine education education.field_of_study business.industry Organ dysfunction Central venous pressure Organ Transplantation medicine.disease Shock Septic Emergency Medicine Female medicine.symptom business Immunosuppressive Agents |
| Zdroj: | Shock. 47:12-16 |
| ISSN: | 1073-2322 |
| Popis: | The growing population of solid organ transplant (SOT) recipients is at a significantly increased risk for developing infections. In some patients, the infection can lead to a dysregulated systemic inflammatory response with acute organ dysfunction. SOT recipients with sepsis tend to have less fever and leukocytosis instances. Moreover, they have diminished symptoms and attenuated clinical and radiologic findings. The current management of sepsis is similar to general patients. It relies mainly on early recognition and treatment, including appropriate administration of antibiotics and resuscitation with intravenous fluids and vasoactive drugs when needed. The infusion of fluids should be closely monitored because elevated central venous pressure levels and fluid overload can be particularly harmful. There is no consensus on how to manage immunosuppressive therapies during sepsis, although dose reduction or withdrawal is suggested to improve the host immunological response. There is compelling evidence suggesting that infections are associated with reduced allograft and patient survival. However, the traditional belief that SOT patients who develop sepsis have worse outcomes than non-transplanted patients has been challenged. |
| Databáze: | OpenAIRE |
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