The clinically relevant diabetic foot syndrome morphology
| Autor: | I. M. Plehutsa, R. I. Sydorchuk, O. Y. Khomko, V. P. Polyovyy, Bilel Khorshani, Petro Vasuliovuch Kyfiak |
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| Rok vydání: | 2021 |
| Předmět: |
diabetes mellitus type 2
Karyolysis Pathology medicine.medical_specialty Necrosis Education Medicine Fragmentation (cell biology) electron microscopy business.industry morphological and microscopic findings Soft tissue medicine.disease Diabetic foot Epithelium medicine.anatomical_structure Apoptosis GV557-1198.995 Ultrastructure medicine.symptom business diabetic foot Sports |
| Zdroj: | Journal of Education, Health and Sport, Vol 11, Iss 5, Pp 262-274 (2021) |
| ISSN: | 2391-8306 |
| Popis: | Polyovyy V., Khorshani Bilel, Sydorchuk R., Kyfiak P., Khomko O., Plehutsa I. The clinically relevant diabetic foot syndrome morphology. Journal of Education, Health and Sport. 2021;11(05): 262-274. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.027 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.027 https://zenodo.org/record/5129576 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2021; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021. THE CLINICALLY RELEVANT DIABETIC FOOT SYNDROME MORPHOLOGY V. P. Polyovyy, Bilel Khorshani, R. I. Sydorchuk, P. V. Kyfiak, O. Y. Khomko, I. M. Plehutsa Bukovinian State Medical University, Chernivtsi, Ukraine Abstract Objective: to evaluate the morphological changes in diabetic foot syndrome emphasizing the ultrastructural cellular changes. Material and methods. Biopsies of the chronic lesions in 120 diabetic foot patients following necessary preparatory stages were studied by histological, histochemical and electron microscopy methods. Results. The inflammatory infiltration and destruction and involving all layers of skin and soft tissue, the phenomena of vacuolation, apoptosis or karyolysis; tissue edema, diffuse infiltration by neutrophils, vascular plethora with stasis, thrombosis, and necrosis were observed. Microcirculatory tract thrombosis exacerbated tissue ischemia, contributing to the progression of pathology. The macrophages' cytoplasm characterized by the presence of phagocytosed and digested microorganisms often intact inside them. The changes in the status of nuclear and perinuclear material were accompanied by compression and dehydration of the cell, which ended in its fragmentation and the formation of tightly contacting bodies of various shapes Conclusions. Morphological changes in diabetic foot syndrome are diverse and uneven, occurring not only on tissue and cellular level but involves subcellular and molecular structures, encouraging further research in this field. Foci of destruction and lysis of the newly formed epithelium are characteristic for diabetic foot, which is not observed in the normal wound process. Keywords: diabetes mellitus type 2; diabetic foot; morphological and microscopic findings; electron microscopy. |
| Databáze: | OpenAIRE |
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