Molecular biosensing mechanisms in the spleen for the removal of aged and damaged red cells from the blood circulation
| Autor: | Yuki Shigemasa, Eriko Ueno, Ikumi Ohgushi, Yoshiaki Sugawara, Yoko Abe, Yuko Hayashi, Fumio Shimamoto |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Hemeproteins
Erythrocytes Hemoglobins Abnormal Spleen Biosensing Techniques Review lcsh:Chemical technology Biochemistry Analytical Chemistry medicine Humans lcsh:TP1-1185 Electrical and Electronic Engineering Instrumentation Heinz Bodies Heinz body formation Hemichrome Chemistry Venous blood Microarray Analysis Atomic and Molecular Physics and Optics hemichrome formation medicine.anatomical_structure Blood circulation Blood Circulation Biophysics Erythrocyte Count Human erythrocytes spleen Hemoglobin biosensing normal human erythrocytes Oxidation-Reduction Heinz body |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 10, Iss 8, Pp 7099-7121 (2010) |
| ISSN: | 1424-8220 |
| Popis: | Heinz bodies are intraerythrocytic inclusions of hemichrome formed as a result of hemoglobin (Hb) oxidation. They typically develop in aged red cells. Based on the hypothesis that hemichrome formation is an innate characteristic of physiologically normal Hb molecules, we present an overview of our previous findings regarding the molecular instability of Hb and the formation of hemichrome, as well as recent findings on Heinz body formation within normal human erythrocytes. Human adult Hb (HbO(2) A) prepared from healthy donors showed a tendency to produce hemichrome, even at close to physiological temperature and pH. Recent studies found that the number of Heinz bodies formed in red cells increased with increasing temperature when freshly drawn venous blood from healthy donors was subjected to mild heating above 37 °C. These findings suggest that Hb molecules control the removal of non-functional erythrocytes from the circulation via hemichrome formation and subsequent Heinz body clustering. In this review, we discuss the molecular biosensing mechanisms in the spleen, where hemichrome formation and subsequent Heinz body clustering within erythrocytes play a key role in the removal of aged and damaged red cells from the blood circulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|