The Impact of a 24-h Ultra-Marathon on Circulatory Endotoxin and Cytokine Profile
| Autor: | Ricardo J. S. Costa, Dean M. Allerton, Alice Wright, Samantha Kirsty Gill, K. Hemming, Paula Ansley-Robson, Slawomir Marczak, Joanne Hankey |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Cytokine profile Physical Exertion Physical Therapy Sports Therapy and Rehabilitation Ultra marathon Running Mountainous terrain Internal medicine Gram-Negative Bacteria Medicine Humans Orthopedics and Sports Medicine business.industry Venous blood C600 Plasma osmolality Endotoxins B900 Endocrinology Immunology Circulatory system Cytokines Sleep Deprivation Bacterial endotoxin Female business Energy Metabolism Digestive System Biomarkers |
| ISSN: | 0172-4622 |
| Popis: | The study aimed to determine circulatory endotoxin concentration, cytokine profile, and gastrointestinal symptoms of ultra-endurance runners (UER, n=17) in response to a 24-h continuous ultra-marathon competition (total distance range: 122-208 km) conducted in temperate ambient conditions (0-20 °C) in mountainous terrain. Body mass and body temperature were measured, and venous blood samples were taken before and immediately after competition. Samples were analysed for gram-negative bacterial endotoxin, C-reactive protein, cytokine profile, and plasma osmolality. Gastrointestinal symptoms were also monitored throughout competition. Mean exercise-induced body mass loss was (mean±SD) 1.7±1.8% in UER. Pre- and post-competition plasma osmolality in UER was 286±11 mOsmol·kg(-1) and 286±9 mOsmol·kg(-1), respectively. Pre- to post-competition increases (p0.05) were observed for endotoxin (37%), C-reactive protein (2832%), IL-6 (3 436%), IL-1β (332%), TNF-α (35%), IL-10 (511%), and IL-8 (239%) concentrations in UER, with no change in the control group (CON; n=12) observed (p0.05). Gastrointestinal symptoms were reported by 75% of UER, with no symptoms reported by CON. IL-10 (r=0.535) and IL-8 (r=0.503) were positively correlated with gastrointestinal symptoms. A 24-h continuous ultra-marathon competition in temperate ambient conditions resulted in a circulatory endotoxaemia and pro-inflammatory cytokinaemia, counteracted by a compensatory anti-inflammatory response. |
| Databáze: | OpenAIRE |
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